While you likely know that long-term inactivity weakens your bones and muscles, you may not realize that it can damage your heart and brain, too. This, in turn, raises your odds of dementia and heart disease, among other conditions, and can lead to early death. But research suggests that getting exercise can help keep these organs healthy and delay or prevent their decline. And if you regularly work up a sweat over a number of years? All the better.

“You really need to think about ways to keep moving,” says Kevin Bohnsack, MD, a family medicine physician at Saint Joseph Mercy Health System in Ann Arbor, Michigan. “Everything that increases your overall activity can ward off that sedentary lifestyle,” he adds—along with the cardiac and cognitive problems that can come with it.